Poker isn't as popular in Macau as it is in other parts of the world, but there are a few casinos that have it. Macau is also home to the highest stakes poker game in the world. The big game has moved around some, it has been in Starworld, City of Dreams, and I heard it is now in the Venetian. My understanding is that it is held in a private suite, so you can't just walk up there and watch.
The number of poker rooms, and the popularity of the rooms, is likely to change without notice (or little notice). But as of September 2015, there were four casinos with poker rooms.
Wynn Macau - Every trip I have had to Macau I have stopped by here to check out the games during off peak times. They have always had at least three tables, and three different structures being spread. They were all no limit Texas Holdem, and if my memory is correct they were 25/50HK, 50/100HK and one that was a lot higher (as in, a single chip was more than I spent on my entire trip). They do have other limits during busier times, and some Omaha. When they are down to three tables, they also always seem to be full. One time I played there on a Sunday night, and then came back Monday morning. At the high limit table, all of the players from the night before were still there.
I'm hesitant to say this is the best poker room in Macau, since "best" is subjective, and I have been here more than any of the others. As you may know, poker rooms can change over time too. But, this does seem to be the most likely to have games going.
Venetian - I haven't checked this one out during many off peak times, but they have had games spread every time I have been there. No Limit Holdem is all I have seen here. Although they have the same lower stakes structure you will see elsewhere, the buy in limits are higher than across the street at the City of Dreams. Despite that, many of the players at a table I played bought in closer to 2,000-6,000 than the 15,000 upper end for the smallest game.
City of Dreams - I haven't been in here too many times, but it seems to be primarily tournaments, weekends, and evenings. I stopped by one weekend and there was a PokerStars Macau Poker Cup tournament going on. It looked pretty good, but I didn't have time to play. Then a few days later I stopped by on a week day shortly after noon, and the place was empty. Just one guy at the desk, and no dealers or players around. I walked around a bit, then decided to get on the list, thinking once the list got going, maybe more would sign up. Then I walked around some more and came back and saw the list only had a few names. I asked the desk about the game and he essentially said the game wouldn't start until 5 or 6. He made it sound like they wouldn't even attempt to start the game sooner (and as I mentioned - there were no dealers around). So, this may just be a local evening game during the week.
Galaxy - The casino has been here for a while, but the poker room just opened up in September 2015. Unforturnately for me it was opening on the same day I was leaving on my most recent trip. So I didn't get to check it out. I am curious to see this room on my next trip. I am also wondering if it will affect some of the other poker rooms. There have been a lot of young players, so maybe poker is becoming more popular in Macau. They said that in addition to cash games, they are planning on hosting tournaments too.
Grand Lisboa - I am only listing this in case you have heard that they have a poker room. They used to, but do not anymore. I can see why. On my first trip, I looked for it, but didn't find it. On my second trip, I found it, and it was the saddest poker game I have ever seen. One low stakes table with maybe three players (at a full table) who had more than 7-8 big blinds, and no one with more than 15.